Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 109 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
Most Useful Reviews
10
Effective combo treatment
153 people found this helpful
This combination works wonders! I bought hyaluronic acid double strength and collagen type II for my mother, and within two weeks, her back and knee pain vanished. She now finds it easier to stand and move about comfortably.
Read More
9
Life-changing relief
52 people found this helpful
This has transformed my life! After suffering from severe knee pain due to arthritis and considering a replacement, I've experienced substantial relief just two weeks after starting hyaluronic acid. Now I can surf again with minimal discomfort.
Read More
9
Knee pain alleviated
45 people found this helpful
After a month of use, I noticed significant relief; my knees no longer hurt after exertion or cold. Furthermore, I've experienced skin hydration improvements too. I will continue this treatment and see how it affects my kidneys.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
Hyaluronic acid aids pelvic pain relief
We explored the effects of high molecular weight hyaluronic acid (HMWHA) on pelvic pain in pregnant women through a pilot study.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
Read More
9
We explored the impact of high molecular weight sodium hyaluronate (HMW-HA) on pelvic pain caused by radiation-induced cystitis. In this prospective study involving 30 patients across seven centers in France, participants received six weekly intravesical instillations of HMW-HA.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
This study looked into how well hyaluronic acid (HA) treatments help relieve pelvic pain in patients with bladder pain syndrome and urinary tract infections. We found that, after long-term use, patients experienced significant reductions in symptoms like urinary bladder pain and urgency. Remarkably, around 75% of participants saw complete relief and needed no further treatments.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Read More
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 109 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Effective combo treatment
153 people found this helpful
This combination works wonders! I bought hyaluronic acid double strength and collagen type II for my mother, and within two weeks, her back and knee pain vanished. She now finds it easier to stand and move about comfortably.
Read More
9
Life-changing relief
52 people found this helpful
This has transformed my life! After suffering from severe knee pain due to arthritis and considering a replacement, I've experienced substantial relief just two weeks after starting hyaluronic acid. Now I can surf again with minimal discomfort.
Read More
9
Knee pain alleviated
45 people found this helpful
After a month of use, I noticed significant relief; my knees no longer hurt after exertion or cold. Furthermore, I've experienced skin hydration improvements too. I will continue this treatment and see how it affects my kidneys.
Read More
9
Reduced irritation
30 people found this helpful
This is the best product on the market for both my joints and skin! I train hard and have found that my knees, shoulders, and elbows feel significantly better. The pain and irritation I previously experienced are almost gone. With consistent use, my workouts have improved considerably. This is an essential supplement for anyone involved in heavy training or dealing with joint pain.
Read More
9
Knee pain stopped
28 people found this helpful
After struggling with a bad knee for years and using glucosamine/chondroitin with noticeable benefits, my knee suddenly hurt severely. I turned to potent painkillers without success. However, after using Now Foods Hyaluronic Acid for six weeks, my knee pain has entirely ceased, and my wife's arthritis has similarly improved. Incredible results!
Read More
Frequently Asked Questions
10
Pelvic pain relief
16 people found this helpful
Due to severe pelvic pain in my hips, I first tried shark cartilage, but only Now Foods' double strength hyaluronic acid has allowed me to forget the pain within a few days! I am truly pleased and grateful for this product.
10
Remarkable recovery
16 people found this helpful
Within two weeks, my mother experienced relief from back and knee pain that had plagued her since childhood thanks to hyaluronic acid and collagen. Now, she feels comfortable and moves freely, and I couldn't be happier for her!
9
Knee pain stopped
28 people found this helpful
After struggling with a bad knee for years and using glucosamine/chondroitin with noticeable benefits, my knee suddenly hurt severely. I turned to potent painkillers without success. However, after using Now Foods Hyaluronic Acid for six weeks, my knee pain has entirely ceased, and my wife's arthritis has similarly improved. Incredible results!
9
Knee pain alleviated
45 people found this helpful
After a month of use, I noticed significant relief; my knees no longer hurt after exertion or cold. Furthermore, I've experienced skin hydration improvements too. I will continue this treatment and see how it affects my kidneys.
10
Effective combo treatment
153 people found this helpful
This combination works wonders! I bought hyaluronic acid double strength and collagen type II for my mother, and within two weeks, her back and knee pain vanished. She now finds it easier to stand and move about comfortably.
9
Life-changing relief
52 people found this helpful
This has transformed my life! After suffering from severe knee pain due to arthritis and considering a replacement, I've experienced substantial relief just two weeks after starting hyaluronic acid. Now I can surf again with minimal discomfort.
8
Significant pain relief
20 people found this helpful
This product made a substantial difference for me. After enduring 12-hour days on concrete, my knees and joints were suffering. Upon starting two pills daily, my knee pain and stiffness decreased by 80%. No other changes were made during this time, making this product highly effective. I also take MSM and curcumin, which I believe enhance the results.
10
Fewer knee pains
8 people found this helpful
I took this for my knee pain. After two weeks, the discomfort reduced significantly and eventually disappeared. Additionally, my skin has improved, and the crow's feet around my eyes have become less visible. I take it in cycles and truly appreciate its effects. I highly recommend this supplement.
7.5
Quick knee recovery
7 people found this helpful
Great product! I used it for about a month along with Glucosamine/Chondroitin. The knee joint pain gradually faded, allowing me to easily climb stairs. I had struggled for nearly a year with little effect prior to this, so I am quite thankful and have recommended it to my daughter for re-delivery.
9
Back pain relief
13 people found this helpful
Works excellently when combined with Glucosamine, Chondroitin, MSM, and other supplements, resulting in nearly complete relief from back pain.
9
Restored joint function
4 people found this helpful
To restore joints, I bought this for my father alongside collagen. After two cans, he no longer feels pain and has experienced restoration of his hip joints. I have used this brand for some time and have found the quality consistently good. After my third pregnancy, I suffered from severe pain in my hip joint, and this product has helped restore normal function. I take one capsule daily, and I have seen improvement in my skin as well. Highly recommended!
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
We analyzed the effects of Hyaluronic Acid-Chondroitin Sulfate (HA-CS) on women experiencing pelvic pain and urinary urgency due to interstitial cystitis/painful bladder syndrome (IC/PBS). Seventeen patients received this treatment while waiting for surgical intervention for urinary issues.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
References
- Gubbiotti M, Rubilotta E, Bacchiani M, Cocci A, Rosadi S, et al. Intravesical administration of highly concentrated hyaluronic acid and chondroitin sulfate as add-on therapy for chemical cystitis induced by Bacillus Calmette-Guérin (BCG) immunotherapy. Int Urol Nephrol. 2025. doi:10.1007/s11255-025-04375-8
- Falabella R, Morra S, Milella L, LA Falce S, DI Fino G, et al. Overactive bladder: results from patients treated by hyaluronic acid-chondroitin sulphate therapy. Minerva Urol Nephrol. 2024. doi:10.23736/S2724-6051.24.05786-0
- Porcaro G, Laganà AS, Neri I, Aragona C. The Association of High-Molecular-Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6, and Vitamin D Improves Subchorionic Hematoma Resorption in Women with Threatened Miscarriage: A Pilot Clinical Study. J Clin Med. 2024;13. doi:10.3390/jcm13030706
- Parente E, Colannino G, Bilotta G, Espinola MSB, Proietti S, et al. Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study. Clin Pract. 2023;13:1123. doi:10.3390/clinpract13050100
- Ghaith AF, Radwan MH, Rashed Taha M, Elbendary MA, Al Damhogy ME, et al. Evaluation of pain and quality of life after hyaluronic acid instillation in addition to botulinum toxin-A injection in women with refractory Interstitial Cystitis/Painful Bladder Syndrome: A pilot study. Arch Ital Urol Androl. 2022;94:447. doi:10.4081/aiua.2022.4.447
- Baboudjian M, Fourmarier M, Clement C, Cherasse A, Graziana JP, et al. Intravesical instillation of high molecular weight sodium hyaluronate in radiation-induced cystitis: a prospective pilot study. World J Urol. 2022;40:141. doi:10.1007/s00345-021-03837-9
- Argüelles Rojas S, Oviedo Ortega JG, Velasco Sordo R. Interstitial Cystitis: Diagnosis and Treatment in a Pregnant Patient. Cureus. 2021;13:e14549. doi:10.7759/cureus.14549
- Cai T, Gallelli L, Cione E, Verze P, Palmieri A, et al. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study. Minerva Urol Nephrol. 2022;74:780. doi:10.23736/S2724-6051.21.04141-2
- Peng YC, Yueh-Hsia Chiu S, Feng M, Liang CC. The effect of intravesical hyaluronic acid therapy on urodynamic and clinical outcomes among women with interstitial cystitis/bladder pain syndrome. Taiwan J Obstet Gynecol. 2020;59:922. doi:10.1016/j.tjog.2020.09.021
- Ekin M, Kaya C, Erdoğan ŞV, Bahçeci E, Baghaki S, et al. The effect of new cross linked hyaluronan gel on quality of life of patients after deep infiltrating endometriosis surgery: a randomized controlled pilot study. J Obstet Gynaecol. 2021;41:263. doi:10.1080/01443615.2020.1755628
- Scarneciu I, Bungau S, Lupu AM, Scarneciu CC, Bratu OG, et al. Efficacy of instillation treatment with hyaluronic acid in relieving symptoms in patients with BPS/IC and uncomplicated recurrent urinary tract infections - Long-term results of a multicenter study. Eur J Pharm Sci. 2019;139:105067. doi:10.1016/j.ejps.2019.105067
- Sherif H, Sebay A, Kandeel W, Othman T, Fathi A, et al. Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome. Turk J Urol. 2019;45:296. doi:10.5152/tud.2018.63600
- Morelli M, Mocciaro R, Venturella R, Albano A, Sacchinelli A, et al. Hyaluronic acid-chondroitin sulfate: a potential factor to select pure stress urinary incontinence in patients with interstitial cystitis⁄painful bladder syndrome and mixed incontinence symptoms. Minerva Ginecol. 2015;67:121.
- Huang W, Wang F, Wu C, Hu W. Efficacy and safety of pirarubicin combined with hyaluronic acid for non-muscle invasive bladder cancer after transurethral resection: a prospective, randomized study. Int Urol Nephrol. 2015;47:631. doi:10.1007/s11255-015-0940-1
- Kim A, Lim B, Song M, Choo MS. Pretreatment features to influence effectiveness of intravesical hyaluronic Acid instillation in refractory interstitial cystitis/painful bladder syndrome. Int Neurourol J. 2014;18:163. doi:10.5213/inj.2014.18.3.163
- Giberti C, Gallo F, Cortese P, Schenone M. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. Ther Adv Urol. 2013;5:175. doi:10.1177/1756287213490052
